Cloned (Comment) | Organism |
---|---|
gene MMP9, cloning of an enzyme fragment, containing an ATG start codon, signal peptide, prodomain sequence, active site, fibronectin II repeat domain and zinc binding sequence,from chondrocyte cDNA, stable recombinant expression in a rat chondrosarcoma cell line | Gallus gallus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
MMP9 inhibitor I | - |
Gallus gallus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc metalloprotease | Gallus gallus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | Gallus gallus | - |
? | - |
? | |
Gelatin + H2O | Gallus gallus Lohman | - |
? | - |
? | |
Laminin + H2O | Gallus gallus | degradation | ? | - |
? | |
Laminin + H2O | Gallus gallus Lohman | degradation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | - |
- |
- |
Gallus gallus Lohman | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
chondrocyte | - |
Gallus gallus | - |
embryo | in the lumen of the cranial and cervical neural tubes | Gallus gallus | - |
neural crest cell | distribution of MMP9 in both emigrating and migrating neural crest cells, overview | Gallus gallus | - |
neural tube | - |
Gallus gallus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | - |
Gallus gallus | ? | - |
? | |
Gelatin + H2O | - |
Gallus gallus Lohman | ? | - |
? | |
Laminin + H2O | degradation | Gallus gallus | ? | - |
? | |
Laminin + H2O | degradation | Gallus gallus Lohman | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
gelatinase B | - |
Gallus gallus |
Matrix metalloproteinase 9 | - |
Gallus gallus |
MMP9 | - |
Gallus gallus |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme inhibition prevents neural crest cells delamination and migration | Gallus gallus |
additional information | enzyme MMP9 promotes neural crest cell emigration from the neural tube by enhancing breakage of laminin at the basement-membrane, mechanism of activity, overview | Gallus gallus |
physiological function | enzyme matrix metalloproteinase 9/gelatinase B is required for neural crest cell migration, which are neuroepithelial progenitors that convert into mesenchyme and migrate along defined paths throughout the embryo. The enzyme plays a role during neural crest cell detachment from the neural tube, overview | Gallus gallus |